
Keep your Library (DB) SIMPLE. No extras...
Custom (plain) columns add more size
Custom (Calculated) gobble up CPU power and RAM


Keep your metadata Neat and Trim. It is Lean or Mean (to your system HW).
Less tags, regularized Author names (same Author, but 16 variant spellings

J B Smith, James Smith, J. B. Smith...)
The actual books (formats) mostly use Disk space, But



Every
Format is another (path to file) entry in a DB table (See #1

)
Currently, lots of CPU cores gains you nothing (basic Library browsing). Fast Disk, Large RAM (you got this covered) and CPU speed are the gains