Well, if the size of the metadata.db scales with the number of books, you would probably have a metadata.db that was 700MB. Note: I am not sure it does, precisely.
Even loading the whole database in RAM all at once, on an ancient computer with only 2GB of RAM, I could handle that -- although I might not be able to run anything at the same time.
The only likely bottleneck is RAM. I assume most newer computers have plenty of RAM anyway.
Best way to tell if it'll work is to try it.