I have had similar issues w/ Calibre since v2.34. they install fine, but freeze at the intializing user interface message. 2.38 and 2.39 can get up and running at first but eventually hit the wall. It is not windows. I use ccleaner religiously an everything else is clean and up to date with no issues. Only Calibre.
I have uninstalled SOS backup as i thought that was the conflict, but still no love. 2.34 works without issue or bug.
very odd.
good luck.
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