Just to add: 99% of my users, being visually impaired, will not already have nor desire a traditional calibre installation, because of its lack of screen reader accessibility. A few of them will already use the command line tools like myself, in which case I will offer the option to point my application at their existing installation. But most of them will not know or care what calibre is and what it can do for them (naturally I will explain on the application's web page and in its documentation that calibre is used behind the scenes).
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