I don't think it's the weight, it's the lack of bezel for good grip. Fine in landscape mode. Continual pressure from grasping that thin edge is not ideal for long stretches. No current model ipad was meant for using in portrait mode one handed for extended periods of time. Making it thinner will actually just make it worse.
Tablets are sleek covered with plastic, aluminum and metal. They are pretty. Ereaders are a little bulkier with a rubberized cover. They are meant to be easy to hold for long periods of time.
If I were you I would not buy the most awesome highly marketed svelt tablet to use as an ereader. I would look for the following things:
(a) no more than 8 inches to keep the weight down,
(b) has a fat ugly side bezel,
(c) thick enough that it is easy to hold, thin enough that it doesn't look ugly,
(d) has custom skins so you can add something rubberized to improve grip,
(e) has high enough resolution that you don't see the screen door effect which hurts readability.
For example the Fire HDX models fit the bill more readily than a Galaxy.
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