There is a discernable difference in the appearance of the text/formatting between the preview pane and the viewer. What looks good in the preview (e..g. the style of font, the amount and placement of white space) fonts sometimes show up as being too extreme or too light; and the same with white space. Mostly I use the preview. Remember I have processed over 100 e-books and only had a problem with 3 of them (at widely different times; the first was several months ago - about 20 e-books, the second was maybe a dozen books later, and the last is the one I am currently working on). All three required massive correction and reformatting of text.
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