Amazon has something called EasyReach, where the majority of the screen is actually the page turn zone. About 3/4 inch on the left side of the device is for previous turn and about a 1 inch zone on the top is to display the toolbar. I do agree they should have an option to flip the sides though.
I often read left hand no problem with a mix of tapping and, as HarryT said, swiping.
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