I'll begin by nominating The Conservationist by Nadine Gordimer, South Africa. The book won the Man Booker and the author won the Nobel.
From
Goodreads:
Mehring is rich. He has all the privileges and possessions that South Africa has to offer, but his possessions refuse to remain objects. His wife, son, and mistress leave him; his foreman and workers become increasingly indifferent to his stewardship; even the land rises up, as drought, then flood, destroy his farm.
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