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IIRC - Avast updates have been known to introduce outbound blocking of calibre, check its exclusion lists
Then check Windows firewall advanced outbound - if you sort the list on the Program column descending then calibre.exe, if present, would be near the top of the list. If it is there question is 'how come', I've always used the MS F/W and I've never had any spurious exclusions.
BR
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