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i suggest the lock effect my be due to a scan for connected devices/ USB ports.
I hypothesize this as I used to experience the same lock out in Win 7 ( cannot use mouse etc for 1 minute+ ) from a different program when it was set to run at start up ( not from calibre) , and i know that calibre scans for connected devices.
This could explain why disabling av/ firewall makes no difference ?
maybe calibre tries to scan a USB port that has not fully woken/activated & the whole PC gets put on hold until that port responds.
dunno what the fix would be, if that is the cause though.
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