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To make a good copy, I suppose I'd scan the whole thing as 300 or 400 dpi tiff, B&W, first--and then scan the images as color or greyscale as appropriate. I'd use the B&W pages to OCR & get text, and insert the color/greyscale pictures during formatting.
If I got bleedthrough on the pictures, and I cared to spend the effort (and if that's the book, it's worth the effort), I'd tinker with them in Photoshop. (Or find out if the author would consider releasing the original images in some kind of digital format, which is possible.)
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