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1) What's your source format? Is the content semantically encoded, ideally in some XML-based format instead of crappy Microsoft Word DOC/DOCX? If so, could there be a fair chance to automatically generate EPUBs from the source documents (if they share a set of document structure types)?
2) EPUB is mostly for offline (mobile) reading, for transferring packaged content from one place to another, and for archival. Of course there are other use cases as well, but as the EPUB format consists of little more than web documents in a zip container, those are the main characteristics in my opinion.
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