I tried removing the hinting on a few fonts, the only one so far that improved as a result was Gentium Basic. It was awful before, and the improvement was dramatic.
However I suspect this is just because the hinting in the original font was so very badly done, it looks better without hinting on my LCD laptop screen too.
Here are screenshots of Gentium Book Basic from my Glo (epub reader), with and without hinting:
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