You don't know how other software, especially bespoke software, might use those registry keys and nor does MS, its not as though they are secret.
Also, I would have thought the registry keys we're talking about are put there by MS Office not Windows Explorer, it just uses them. The sample I've posted is for Office 2007, MS Office 2010 and 2013 may do something different - like not use DDE.
BR
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