I advise my students (and any serious scholar) not to use the Calibre E-Book Viewer--it is because one cannot easily
underline (or mark-up) the text. When I read something I want to mark, I need to go to the editor (yuck).
But in an email, I simply select the text and hit
underline.
I can do the same with a right-click in any word processing program, and I can easily
underline in Adobe Acrobat.
When Calibre adds an easy right-click function to
underline, I'll start telling my students to use it.