Quote:
Originally Posted by agnostyc
I mean add new bookmarks in pdf, change text in .docx files etc.. located in my calibre-library. 
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If you uncheck PDF and DOCX in
Preferences->Interface->Behaviour->Use internal viewer for: then when you view those file types whatever programs you have in your Operating System file associations will be used to open the file - eg Adobe Acrobat for PDF's and MS Word for DOCX's
If you then View the PDF it will be opened in Acrobat where you can annotate etc, when you do a regular Save (ctrl/s) in Acrobat it will save (overwrite) the PDF in the library book folder. Same with DOCX - except you'd edit in Word.
BR