What some people do is make a generic EPUB and then tweak a copy for each platform giving difficulty.
A business that specializes in conversion will probably have a compilation of CSS derived from long experimentation that contains workarounds for common devices -- that is in part what they are paid for. @Hitch is a member here and runs one such business (and we know her and know she knows what she is talking about), you might be interested in her professional consultation.
Or tell us what particular discrepancies you are seeing and the various EPUB gurus here might be able to offer suggestions.
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