I recently got a new Kindle, and have been reading in in landscape mode because it's easier for me to hold it in two hands while in landscape mode. However, that's mainly because I don't yet have a case, and without a case, holding it in one hand is a bit clumsy/uncomfortable for me. Once I get a case and can do one-handed holding again, I might very well go back to portrait (which I did on my Nook out of necessity). I suppose it depends on which way is easier to hold with a case.