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I was having a somewhat similar problem with Calibre and then another program that I added.
The problem was traced to my antivirus suite. Even though I told Windows that it was okay to run the programs, my antivirus software apparently disagreed and, without informing me, blocked them from running. I found the settings in the antivirus software where I could set it to allow Calibre and the other program and everything worked fine.
So that might be one place to look.
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