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Again, it heavily depends. Let me give a recent example. To a book I added the whole Sabon Next LT font family. That is a regular, italic, bold and bolditalic. Font sizes are (in same order) 146 KB, 142 KB, 129 KB, 123 KB. After optimization the bold and bolditalic are removed (they are not used). The regular is now 61KB and the italic 49KB. The characters used of course differs between regular and italic.
This is just one example. Other one is a font only used for dropcap and headers, Smythe. Standard font is 89KB, after optimization in a book it is 15KB. In the same book is also the Sabon font. The regular size there is 59KB and the italic 40KB.
It really differs per font and per usage.
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