Big question is, if you want to embed the fonts. If you do, the actions will be different than if you don't. Also, I think InDesign can create an ePUB with a stylesheet instead of inline styles like the example you give. That will make work a lot, and I mean a lot, easier.
Presuming you do not want to embed fonts (as this would not work on mobi files anyway afak), you can just search for font-family: 'Futura Light'; and replace that by nothing. That would work in the example you give.
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