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this may or may not be answering your question, but i have a 7" (1920x1200) and a 10" (2560x1600) tablet, and i find that a nice low-strain setup is to have white text on a black background. basically, night mode. i use it during the day (indoors). both tablets' resolution specs give a pixel density of 300dpi-plus, so as far as sharpness / crispness they're equal. one just has more area than the other.
compared to my kobo glo (black text on white/gray background), there's no big difference in eye strain.
then again, i don't read for more than 2 hours at a time anyways. i gotta eat, pee, stretch, so invariably i have 5-10min breaks every so often anyways.
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