I'm reminded a bit of my school days: watching students work their hearts out trying to learn subjects - and when that failed, to memorise enough to get past the exams. Meanwhile other students seem to breeze through exactly the same subjects.
I suppose the most common situation is that if you never get comfortable with a subject or discipline, or whatever, that you won't enjoy it so you won't try to spend 10,000 hours trying to become an proficient at it. You will, presumably, find something for which you have more aptitude, before committing such time.
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