I've been using a Dell Venue 8 Pro as my eReader for a while now. It's an 8.1" Win8.1 tablet with a 1280x800 screen resolution which works very well for reading, though I'm beginning to have several age related vision difficulties and use a bit larger text than what would be found in the typical paperback book.
I still haven't found a reading app that I am completely comfortable with. I run calibre with a large library on my DV8p and all DRM has been removed from the books so format conversion is easy. I'm currently using Book Bazaar Reader, a Modern (nee Metro) app. It functions well, but ignores a lot of a book's formatting. Calibre's ebook-viewer and the Kindle desktop version also work well but suffer noticably in a touch only environment.
TouchMousePointer helps a great deal, but doesn't solve all of the handling issues.