Yes, you can "force" various devices, specifically iBooks on the iPad, iPhone, AmazonKindle KF8 devices (Kindle Fire, Paperwhite, HDX models), KoboBooks, and NookKids' (caveats here) open only in landscape view. However,there's no simple, "upload a Word file" DIY-type method to make these books. (n.b.: there is "Kindle Kids Book Creator" software out now, that can take jpegs or a PDF and make a book that does this).
However, for the rest, you'll need some knowledge of HTML and CSS, and these books, called "fixed-format" aren't the simplest to make. For Amazon, to create Region Magnification (called pop-up text), which you need for the widest distribution, takes some pretty solid coding skills; you literally place each word using x-y coordinates.
Yes, you can make an ePUB with a table of contents, but not without an NCX.
Vis-à-vis aggregators: be advised, many if not all aggregators (with the exception of InDigital) will NOT accept Fixed-format books for distribution, particularly to Amazon. This is because distributors upload books via FTP, in a singular format (reflowable ePUB). Make sure you ask BookBaby.
With regard to B&N, please be advised that B&N does not accept "NookKids'" books from self-publishers; you have to have a publishing contract with them that specifically allows you to be a NookKids' publisher. The application starts with a section asking you to list your top 25-selling titles, and the volume of sales for each.
Hope that helps.
@Ducky: I think that this likely should have been moved to the Workshop, rather than the Writer's Corner, FWIW. It's more a techie issue than a writer's issue, IMHO.
Hitch