Indeed, try WINE. Sometimes it works, sometimes it doesn't... I have never gotten ADE2.0 to work for me. But 1.7 works fine, and is easily run under WINE.
Now, I never got the DeDRM tools to work smoothly with WINE, so I just use my dual-boot WinXP partition on the rare occasion I need to access an ADE book. Then it goes straight into calibre.
I strongly believe that you should never nuke a working Windows/OSX install Just Because -- it could always come in handy, and all it costs is disk space, which is usually not a problem.
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