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The Heart of a Dog, by Mikhail Bulgakov, might qualify (or might not, as the dog is involved in a strange experiment!) (published 1925) -
"A rich, successful Moscow professor befriends a stray dog and attempts a scientific first by transplanting into it the testicles and pituitary gland of a recently deceased man. A distinctly worryingly human animal is now on the loose, and the professor's hitherto respectable life becomes a nightmare beyond endurance. An absurd and superbly comic story, this classic novel can also be read as a fierce parable of the Russian Revolution."
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