Although having 2 IP addresses on the same subnet may not have appeared to cause problems, unless the underlying software effectively ignores one of them then various IP protocol bits won't work correctly. For example, broadcasts will trigger responses from both addresses, making it appear to be two computers when in fact it is one. Outgoing packets are permitted to use either, meaning that the NAT system in your router can get confused.
But onto the more important stuff: I interpret your response as saying that you cannot connect to the content server from your portable device (tablet?). That would mean that something between your tablet and calibre is blocking network packets. If it isn't the router then it is the AV/firewall on the laptop, which points a finger at avast.
You could try rebooting the laptop in "safe mode", starting calibre, and seeing if CC can connect. If is can then we know that the problem is in software that is loaded while you laptop is booting, probably avast. You could try disabling avast to see if that fixes it, but my experience has been that avast is very hard to completely disable. You could look for avast logs to see if it is unhappy with calibre. You could also try rolling calibre back to what you had before.
I am certainly willing to look at debug logs. It is possible that they might tell us something.
|