The full screen reading tweak along with setting margins and padding to zero in Calibre gets rid of all margins. You can literally have the screen full of text from edge to edge with no unofficial patches. No page number that way but it can easily be shown with a single tap.
However, there seems to be a bug with orphans and widows where even after disabling them (a value of 1) there are sometimes still blank lines at the end of the page. This seems to depend on the book though, one I read was nearly flawless, the other has every other page two lines short.
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