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What ApK said.
In terms of user-friendliness, kdp is extremely easy. If you have a MS word document, you can create a finished ebook. (Although if you want high-quality meta-data and internal formatting, you're going to need more sophisticated software.)
Createspace requires a PDF document sized to one of the standard print specifications. I believe there's also an extra charge for extended distribution, and other online vendors -- such as Barnes & Noble -- don't always like to display the cover images of books published via Amazon.
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