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First, Can you open the ebook again in calibre?
As to opening the ebook in your favorite ebook viewer, assuming you are using some version of windows, if the message is "application can't be found" the file system does not recognize the ebook file as having any program associated with it.
Try highlighting the ebook you wish to read, right click on it and select open with. Choose your ebook reader program from the list of programs available.
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