SOLVED... (I think)
I noticed when using the mouse wheel in the editor to fast-scroll through a document that I got a popup from a program called "HandyAndy.exe" that said that there were several hundred hotkeys detected in the last 1200ms or something like that, and asked did I want to keep monitoring.
I checked what HandyAndy.exe is, it's a component of the Andy Android Emulator, I guess what HandyAndy does is look for mouse movements and translate them into touchscreen emulated gestures for the android emulator to work.
I task-killed HandyAndy and all seems to work fine in Calibre. Funny thing is that this does NOT affect anything else and never seemed to affect Calibre v1.xx either, only started when I upgraded to v2 this week.
Anyway, sorry for the false alarm, looks like my problem is solved.
Thanks
-TRJB
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