If an appeal gets denied, the Apple has to move up to the next level. That would be either an en banc hearing (usually the first level appeal gets heard by a panel which is a subset of the entire circuit court. I'm not sure if that is the case here, but it's the norm for that to happen. En banc is a hearing by the entire circuit court), or an appeal to the Supreme Court, which can choose to hear it or not. Most of the predictions that I have read think that it will go to the Supreme Court and they will hear it.
Apple can not re-file the same appeal except in some special circumstances. That's one reason that Apple's appeal had so many different points, there is no do over, so they had to hit all the possible reasons to overturn.
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