why use the portable app? i have the desktop version at home; my libraries are in dropbox. if i want to pull up calibre on my work computer, instead of installing calibre locally, i would run the portable from dropbox. that is the very definition of why you would want to run it as a portable app. instead of carrying around a thumb drive, i keep my portable apps in dropbox.
as DoctorOhh also chipped in, i have been running it this way for years. no problems with it. now it doesn't work.
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