What do you mean, "run from Dropbox"? calibre is not a cloud app.
If you mean, storing the calibre portable folder in your Dropbox sync folder, I don't know why it won't work*, but it is a very bad idea to do so -- it is a good thing it didn't work.
* Maybe Dropbox was locking up the tempfiles calibre tried to create or something?
Last edited by eschwartz; 08-10-2014 at 02:55 AM.
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