If I may give you a good tip... Brush up on basic HTML and CSS skills. That will help you to a large extent... There are some good guides out there. One is on this forum by Pablo (aimed for e-books) and I believe it is also published on the mobileread wiki.
In this case <strike></strike> or <s></s> is deprecated and might not be supported on the readers. To be fair, I haven't come across a reader that did not support it though.
Layout and styling should be done as much as possible via stylesheets. That will make your book smaller in size, easier to maintain and better performing.
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