We're considering two related yet separate concepts here:
- The library's management, which is Calibre's domain, and
- The actual reading (consulting, searching into, etc), which is your device's domain.
For my part, without a doubt, keep your library on whatever system you're using Calibre on. That's where you add and remove books, and manage their metadata. That's also where you manage your backups.
From there, you can think about populating your device. I've got a Cybook Orizon, and its 2(+4)GB could host my entire library if I wanted to, but I tend to only put the two or three hundred books I'm currently reading or may want to read on a whim. Every few days I browse Calibre and use Reading Lists to refresh my device. I don't do it because I want to keep some free space, I just do it so that navigating the device's library isn't too much of a chore.
Now, nothing stops you from uploading your entire library from Calibre to your device, or you can use some of Calibre's features to easily "swap" whole collections of books in and out of your device. But always keep in mind that ideally, what's on your device is only a reflection of Calibre's library, be it complete or partial.
Hope that helps a little.
N.
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