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I get migraine headaches but I don't notice a flicker on my e-readers. That would make me stop using them. The backlit screens are a bit hard to read on but I find the lit e-ink screens very comfortable for reading. I can adjust the font and the light to be just how I like it and it's probably better than a reading lamp and a paper book for me. (Particularly if the reading lamp uses a fluorescent light. Those are bad for headaches.)
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