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Sigil doesn't have a problem because it enforces its own organization on the file when it brings it in. It doesn't have to try to figure things out. It also doesn't let you save when the file is badly formed. These give Sigil a leg up on that score, but these can be deficiencies as well if you are working with total junk in the first place.
People with brand new shiny e-readers and tablets can handle the big files, but there are lots of us out here with older but very serviceable machines. It is no problem to break at the start of a chapter. It takes a pretty large chapter, generally non-fiction to be over 250k long.
Also using the preview window with large files will slow it up because every change will require reformatting the whole file in the preview window. Leave the window unsync'ed and manually re-synch it to check your results.
Those having trouble might considering downloading a file at random out of the MR library and see how fast editing goes with that file. It might give a clue as to whether the file you are working on is a problem because it is full of extra code or something or whether the program is causing the problem.
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