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Thanks for the suggestions.
First: lowering the resolution to 1920x1080 is not an option. I'm not going to spend the money on a 2560x1440 monitor to get as high a DPI as possible, and then make it blurry by lowering to a non-native resolution. My goal was to get a 27" monitor with a working space of (at least) 1920x1080, and also be as sharp as possible. A 25660 x 1440 monitor set to 133% achieves this. (2560 / 1.333333 = 1920, and so forth, at 108 dpi, while a normal 1920x1080 monitor as large as 27 inch would only be 81 dpi.)
Second: I am using the dual-link DVI cable that came with the monitor, and my graphics card is powerful enough to control this screen (nVidia GTX 560 Ti.)
Third: No other programs have any lag, except for LibreOffice, which is as slow as Calibre is.
Fourth: Disabling the colored row I set for "Read" books makes calibre a tad faster, but not by much.
In the end, if there is not an easy fix for this, I'll just leave it be. On this monitor, I just dock calibre to the right of the screen using Aero Snap, and then stretch it to display all my columns. After that, I normally don't resize it.
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