To some degree, you are going to have to accept that the layout is not always going to be what you wish because the text size can be increased to where it will cause problems.
But very frequently, you can reach a happy medium where in most of the sizes you expect the book to be used it, it will look good.
If the small pictures are in fact really small and you can rescan the pictures again at a higher resolution, it will help when they are resized.
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