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@dunawaysm A common reason for installing portable versions of programs in preference to installed versions is to avoid the Windows Registry. That rationale doesn't apply to calibre, because the installed versions don't use the registry. All configuration data is stored in the %USERPROFILE%\Appdata\Roaming\calibre folder, which can be relocated via an environment variable setting.
The portable version is the 32bit build, that's to ensure can be used on any windows computer - public access computers are often 32bit. The major difference between the 32bit and 64bit builds is that the 32bit build may fail to convert some very large books due to memory limits.
There are also issues regarding location of libraries - the portable version anticipates they will be located within in the "Calibre Portable" folder. Accessing libraries elsewhere works fine - but its a tad inconvenient.
BR
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