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On my PRS 300 your single block file will show up as 1 page, it won't open, that is, if it doesn't lock up the reader.
You will find, depending on the material, that actions in the editor will work faster if the chunks are smaller. As theducks said, you can control the damage from search and replace gone wrong if you work on a chapter size chunk at a time.
Your experience may vary. I work on PDF conversions which are full of errors and require endless, so it seems, search and replaces and therefore many chances to go wrong. If you work on original material which is not endlessly buggy, this may be less of an issue. All it will take is one search and replace gone invisibly wrong and finding it out several hours later to convince you that confining your search and replace can be a very useful stress reduction strategy.
Case in point from me yesterday. The book has lots of sentences where the wordsruntogether and even at the end of the sentence it goes from period .To the next word.
An easy search and replace case, right? Only if there are no images because image.png becomes image. png and will not be found or displayed!
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