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The cynical side of me wants to respond that there are only Wrong answers with commas, there are very few strictly Right.
Yes, reading a guide suitable for your region will given you an idea of what is expected in formal writing. After that you need to read, read, read ... and pay attention. The rules for fiction tend to be a bit more relaxed to what you see in formal writing - make your writing too formal and it will come over as stiff and awkward. As VyderScope already noted, a professional editor can help you with that.
The most important rule is simple: make the meaning clear. The old "Let's eat, Grandpa" is the most commonly cited example of this. When reading through your style guide pay particular attention to the comma rules that relate back to this one (that affect the meaning/clarity of the text). Everything else is window dressing that can be fixed up in the final editing phase.
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