@djlewis - You could try Firefox 28 + EPUBReader 1.4.2.4. They give me what I think of as smooth scrolling via mouse wheel. you'll need to change its settings to a vertical web-like style. You might want to adjust you mouse settings, mine's set to 4 - gets a bit laggy if its higher, and jerky if its lower. I don't think I did any special changes to Firefox settings via Options or about:config.
It took Mozilla quite a few years to get smooth scrolling via mouse wheel working properly, cant recall when they finally cracked it - within the last couple of years I would think.
Be aware that EPUBReader will store a copy of anything you read into in the firefox profile - ie it creates yet another ebook library Ψ
BR
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