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This type of problem is in many cases due to the OS confusing a non-mouse device on a port as being a mouse, mostly this is confusing some serial input (RS232 or USB with USB->RS232 converter) as a serial mouse. Most people do not have RS232 devices any more unless they have some special need, but I mention it just in case, and this problem can exist with Win 8.x having experienced it myself with applications relying on RS232 inputs.
This happens with applications that look for devices on a port and, of course, Calibre does that when it looks to see if a reader of some sort is connected.
Whatever, in any event, I would suggest going into Control Panel>Device Manager (or just type device manager with the Win 8 Start page open and delete all the mice that may appear (touchpad too if you are using a notebook). Be especially alert if a serial mouse is listed (which one assumes on a modern PC you would not be using) or any other mouse type other than the one you are using (if one assumes you are using a bluetooth mouse then be alert if a USB mouse is listed).
With nothing connected to your PC other than the mouse, reboot the PC and it will reload the driver for your mouse.
If the problem persists still, and if it only occurs if your reading device is connected, then my next move would be to uninstall and then reinstall the device if is of a type that appears as a multimedia device in Control Panel>Devices and Printers (or type Devices and Printers on the Win 8 Start Page); it will probably only appear as such if it is a multimedia capable device such as a Tablet or Smartphone that you are using for reading (which I assume excludes the Kindle 3 if that is what is connected).
Beyond that I would start looking at anything else that may be permanently connected to the PC such as a USB scanner or printer, and see if the problem exists with them disconnected.
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