I've found there's really not that much difference between calibre-edit's regex engine and Sigil's. And most of those differences are very "edge case" kind of stuff: searching for unicode code-points, and the like. Mostly, calibre-edit's regex engine just adds a few things that weren't in Sigil's: like allowing variable-length lookbehinds, and matching the start/end of words with \m \M.
If case matters ... then case matters. And if so, the appropriate box needs to be checked.
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