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Well, not in itself. However, be aware that some readers (the nook I believe) ignore font-family settings in the body and HTML class.
Another thing would be your line for a 'witregel'. The way you define it in your HTML might result that some reader systems would actually ignore the line since it has no content. You would be best of by either putting a in the paragraph tag or have the paragraph following the 'witregel' a margin-top to create the effect. The choice is yours, depends on how much a purist you are.
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