Yes, it is possible to remove brackets from titles, using regexp.
I would suggest that you remove all series information from the titles, and store it in the fields intended for that purpose. That can be done using bulk metadata search and replace with regexp as well.
It is bad to store series information in the title, you will most likely change your mind about formatting and want to change it in the future. Metadata lookup may fail, because the title has extra information. Also it becomes difficult to update if you have the series information stored both in the intended fields and the title, and plug-ins that are used to manipulate series information most likely don't handle the title.
If you want the series information in the title or the filename on the device, then you can use a plugboard and/or a save template to add that "on the fly".
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