I'll third
Behold, Here's Poison.
This has been nominated before for Romance month, but never won. I enjoyed it tremendously, so I'll nominate
The Time Traveler's Wife by Audrey Niffenegger.
Quote:
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Audrey Niffenegger's dazzling debut is the story of Clare, a beautiful, strong-minded art student, and Henry, an adventuresome librarian, who have known each other since Clare was six and Henry was thirty-six, and were married when Clare was twenty-three and Henry thirty-one. Impossible but true, because Henry is one of the first people diagnosed with Chrono-Displacement Disorder: his genetic clock randomly resets and he finds himself misplaced in time, pulled to moments of emotional gravity from his life, past and future. His disappearances are spontaneous and unpredictable, and lend a spectacular urgency to Clare and Henry's unconventional love story. That their attempt to live normal lives together is threatened by something they can neither prevent nor control makes their story intensely moving and entirely unforgettable.
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